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ca bmk2202 anti rabbit biotinylated vector lab  (Vector Laboratories)


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    Vector Laboratories ca bmk2202 anti rabbit biotinylated vector lab
    Ca Bmk2202 Anti Rabbit Biotinylated Vector Lab, supplied by Vector Laboratories, used in various techniques. Bioz Stars score: 96/100, based on 2773 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ca+bmk2202+anti+rabbit+biotinylated+vector+lab/Mouse+on+Mouse+(M%2EO%2EM%2E+)+Basic+Kit/pmc11163201__mmc1-23-220-224
    Average 96 stars, based on 2773 article reviews
    ca bmk2202 anti rabbit biotinylated vector lab - by Bioz Stars, 2026-09
    96/100 stars

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    Related Articles

    Immunohistochemistry:

    Article Title: DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis
    Article Snippet: Name Supplier Reference Quantity/Dilution Glutamine synthétase BD Biosciences, Franklin Lakes, NJ 610518 1/400 (IHC) Ki67 Abcam, Cambridge, UK Ab16667 1/300 (IHC) Cleaved Caspase 3 Cell Signaling, Danvers, MA #9661 1/600 (IHC) DLK1 Proteintech, San Diego, CA 10636-1-AP 1/1000 (WB) Cyclin A2 Abcam, Cambridge, UK ab 32386 1/100 (WB) Cyclin B1 Cell Signaling, Danvers, MA 4138 1/200 (WB) FOXM1 Santa Cruz Biotechnology, Dallas, TX sc-376471 X 10ug (CHIP) , 1/100 (IHC) CD45 -PE BD Biosciences, Franklin Lakes, NJ 553081 1/400 (flow cytometry) CD31 – BV605 BioLegend, San Diego, CA 102427 1/300 (flow cytometry) CD11b – BV510 BD Biosciences, Franklin Lakes, NJ 562950 1/400 (flow cytometry) CD11c – PE Cy.7 BD Biosciences, Franklin Lakes, NJ 558079 1/400 (flow cytometry) F4/80 – Percp Cy 5.5 Thermofischer, Waltham, MA 130-118-466 1/300 (flow cytometry) Ly6C – V450 BD Biosciences, Franklin Lakes, NJ 560594 1/200 (flow cytometry) Ly6G – APC Cy.7 BioLegend, San Diego, CA 127624 1/200 (flow cytometry) TCF-4 Millipore, Burlington, MA 05-511 3ug (CHIP) b-catenin BD Biosciences Franklin Lakes, NJ 610154 1/50 (IHC), 10μg (CHIP) HNF-4a Santa-Cruz, Dallas, TX sc-6556x 10μg (CHIP) H3K27ac Active Motif, Carlsbad, CA 39133 10μg (CHIP) H3K4me3 Active Motif, Carlsbad, CA 39159 5 μg (CHIP) H3K4me1 Active Motif, Carlsbad, CA 39297 10μg (CHIP) b-actin Sigma-Aldrich, Saint-Louis, CA A5441 1/5000 (WB) FADD Elabscience, Houston, TX E-AB-10318 1/1000 (WB) mouse on mouse kit Vector Lab, Newark, CA BMK2202 Anti-rabbit biotinylated Vector Lab, Newark, CA BA-1000 1/200 (IHC) Histofine kit Microm Microtech, Brignais, France F/414341F Anti-rabbit HRP Cell Signaling, Danvers, MA 7074 1/2000 (WB) Anti-mouse HRP Cell Signaling, Danvers, MA 7076 1/2000 (WB) 13 Figure S1: Schematic representation of experimental models 14 A-B: Generation of Apc∆hep-DLK1/DIO3∆WRE model with AAV8 CRISPR/Cas9 constructs targeting the DLK1-WRE site in Apclox/lox model: tamoxifen-induced Apc deletion was conducted one month after AAV8 injection, which is the time that we have identified as optimal for gene editing2 in pretumoral model (A) and tumoral model (B); C: Generation of β- cateninDExon3 DLK1/DIO3∆WRE model with concomitant injection of AAV8 CRISPR/Cas9 constructs targeting Ctnnb1 and the DLK1-WRE site; D: Kinetics of hepatocyte sorting: GFP- positive hepatocytes were sorted from tumoral Apc∆hep livers in early-steps by flow cytometry (ARIA3, BD).

    Article Title: DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis
    Article Snippet: Glutamine synthétase BD Biosciences, Franklin Lakes, NJ 610518 1/400 (IHC) Ki67 Abcam, Cambridge, UK Ab16667 1/300 (IHC) Cleaved Caspase 3 Cell Signaling, Danvers, MA #9661 1/600 (IHC) DLK1 Proteintech, San Diego, CA 10636-1-AP 1/1000 (WB) Cyclin A2 Abcam, Cambridge, UK ab 32386 1/100 (WB) Cyclin B1 Cell Signaling, Danvers, MA 4138 1/200 (WB) FOXM1 Santa Cruz Biotechnology, Dallas, TX sc-376471 X 10ug (CHIP) , 1/100 (IHC) CD45 -PE BD Biosciences, Franklin Lakes, NJ 553081 1/400 (flow cytometry) CD31 – BV605 BioLegend, San Diego, CA 102427 1/300 (flow cytometry) CD11b – BV510 BD Biosciences, Franklin Lakes, NJ 562950 1/400 (flow cytometry) CD11c – PE Cy.7 BD Biosciences, Franklin Lakes, NJ 558079 1/400 (flow cytometry) F4/80 – Percp Cy 5.5 Thermofischer, Waltham, MA 130-118-466 1/300 (flow cytometry) Ly6C – V450 BD Biosciences, Franklin Lakes, NJ 560594 1/200 (flow cytometry) Ly6G – APC Cy.7 BioLegend, San Diego, CA 127624 1/200 (flow cytometry) TCF-4 Millipore, Burlington, MA 05-511 3ug (CHIP) b-catenin BD Biosciences Franklin Lakes, NJ 610154 1/50 (IHC), 10μg (CHIP) HNF-4a Santa-Cruz, Dallas, TX sc-6556x 10μg (CHIP) H3K27ac Active Motif, Carlsbad, CA 39133 10μg (CHIP) H3K4me3 Active Motif, Carlsbad, CA 39159 5 μg (CHIP) H3K4me1 Active Motif, Carlsbad, CA 39297 10μg (CHIP) b-actin Sigma-Aldrich, Saint-Louis, CA A5441 1/5000 (WB) FADD Elabscience, Houston, TX E-AB-10318 1/1000 (WB) mouse on mouse kit Vector Lab, Newark, CA BMK2202 Anti-rabbit biotinylated Vector Lab, Newark, CA BA-1000 1/200 (IHC) Histofine kit Microm Microtech, Brignais, France F/414341F Anti-rabbit HRP Cell Signaling, Danvers, MA 7074 1/2000 (WB) Anti-mouse HRP Cell Signaling, Danvers, MA 7076 1/2000 (WB) Figure S1: Schematic representation of experimental models A-B: Generation of Apc∆hep-DLK1/DIO3∆WRE model with AAV8 CRISPR/Cas9 constructs targeting the DLK1-WRE site in Apclox/lox model: tamoxifen-induced Apc deletion was conducted one month after AAV8 injection, which is the time that we have identified as optimal for gene editing2 in pretumoral model (A) and tumoral model (B); C: Generation of β- cateninDExon3 DLK1/DIO3∆WRE model with concomitant injection of AAV8 CRISPR/Cas9 constructs targeting Ctnnb1 and the DLK1-WRE site; D: Kinetics of hepatocyte sorting: GFPpositive hepatocytes were sorted from tumoral Apc∆hep livers in early-steps by flow cytometry (ARIA3, BD).

    Western Blot:

    Article Title: DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis
    Article Snippet: Name Supplier Reference Quantity/Dilution Glutamine synthétase BD Biosciences, Franklin Lakes, NJ 610518 1/400 (IHC) Ki67 Abcam, Cambridge, UK Ab16667 1/300 (IHC) Cleaved Caspase 3 Cell Signaling, Danvers, MA #9661 1/600 (IHC) DLK1 Proteintech, San Diego, CA 10636-1-AP 1/1000 (WB) Cyclin A2 Abcam, Cambridge, UK ab 32386 1/100 (WB) Cyclin B1 Cell Signaling, Danvers, MA 4138 1/200 (WB) FOXM1 Santa Cruz Biotechnology, Dallas, TX sc-376471 X 10ug (CHIP) , 1/100 (IHC) CD45 -PE BD Biosciences, Franklin Lakes, NJ 553081 1/400 (flow cytometry) CD31 – BV605 BioLegend, San Diego, CA 102427 1/300 (flow cytometry) CD11b – BV510 BD Biosciences, Franklin Lakes, NJ 562950 1/400 (flow cytometry) CD11c – PE Cy.7 BD Biosciences, Franklin Lakes, NJ 558079 1/400 (flow cytometry) F4/80 – Percp Cy 5.5 Thermofischer, Waltham, MA 130-118-466 1/300 (flow cytometry) Ly6C – V450 BD Biosciences, Franklin Lakes, NJ 560594 1/200 (flow cytometry) Ly6G – APC Cy.7 BioLegend, San Diego, CA 127624 1/200 (flow cytometry) TCF-4 Millipore, Burlington, MA 05-511 3ug (CHIP) b-catenin BD Biosciences Franklin Lakes, NJ 610154 1/50 (IHC), 10μg (CHIP) HNF-4a Santa-Cruz, Dallas, TX sc-6556x 10μg (CHIP) H3K27ac Active Motif, Carlsbad, CA 39133 10μg (CHIP) H3K4me3 Active Motif, Carlsbad, CA 39159 5 μg (CHIP) H3K4me1 Active Motif, Carlsbad, CA 39297 10μg (CHIP) b-actin Sigma-Aldrich, Saint-Louis, CA A5441 1/5000 (WB) FADD Elabscience, Houston, TX E-AB-10318 1/1000 (WB) mouse on mouse kit Vector Lab, Newark, CA BMK2202 Anti-rabbit biotinylated Vector Lab, Newark, CA BA-1000 1/200 (IHC) Histofine kit Microm Microtech, Brignais, France F/414341F Anti-rabbit HRP Cell Signaling, Danvers, MA 7074 1/2000 (WB) Anti-mouse HRP Cell Signaling, Danvers, MA 7076 1/2000 (WB) 13 Figure S1: Schematic representation of experimental models 14 A-B: Generation of Apc∆hep-DLK1/DIO3∆WRE model with AAV8 CRISPR/Cas9 constructs targeting the DLK1-WRE site in Apclox/lox model: tamoxifen-induced Apc deletion was conducted one month after AAV8 injection, which is the time that we have identified as optimal for gene editing2 in pretumoral model (A) and tumoral model (B); C: Generation of β- cateninDExon3 DLK1/DIO3∆WRE model with concomitant injection of AAV8 CRISPR/Cas9 constructs targeting Ctnnb1 and the DLK1-WRE site; D: Kinetics of hepatocyte sorting: GFP- positive hepatocytes were sorted from tumoral Apc∆hep livers in early-steps by flow cytometry (ARIA3, BD).

    Article Title: DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis
    Article Snippet: Glutamine synthétase BD Biosciences, Franklin Lakes, NJ 610518 1/400 (IHC) Ki67 Abcam, Cambridge, UK Ab16667 1/300 (IHC) Cleaved Caspase 3 Cell Signaling, Danvers, MA #9661 1/600 (IHC) DLK1 Proteintech, San Diego, CA 10636-1-AP 1/1000 (WB) Cyclin A2 Abcam, Cambridge, UK ab 32386 1/100 (WB) Cyclin B1 Cell Signaling, Danvers, MA 4138 1/200 (WB) FOXM1 Santa Cruz Biotechnology, Dallas, TX sc-376471 X 10ug (CHIP) , 1/100 (IHC) CD45 -PE BD Biosciences, Franklin Lakes, NJ 553081 1/400 (flow cytometry) CD31 – BV605 BioLegend, San Diego, CA 102427 1/300 (flow cytometry) CD11b – BV510 BD Biosciences, Franklin Lakes, NJ 562950 1/400 (flow cytometry) CD11c – PE Cy.7 BD Biosciences, Franklin Lakes, NJ 558079 1/400 (flow cytometry) F4/80 – Percp Cy 5.5 Thermofischer, Waltham, MA 130-118-466 1/300 (flow cytometry) Ly6C – V450 BD Biosciences, Franklin Lakes, NJ 560594 1/200 (flow cytometry) Ly6G – APC Cy.7 BioLegend, San Diego, CA 127624 1/200 (flow cytometry) TCF-4 Millipore, Burlington, MA 05-511 3ug (CHIP) b-catenin BD Biosciences Franklin Lakes, NJ 610154 1/50 (IHC), 10μg (CHIP) HNF-4a Santa-Cruz, Dallas, TX sc-6556x 10μg (CHIP) H3K27ac Active Motif, Carlsbad, CA 39133 10μg (CHIP) H3K4me3 Active Motif, Carlsbad, CA 39159 5 μg (CHIP) H3K4me1 Active Motif, Carlsbad, CA 39297 10μg (CHIP) b-actin Sigma-Aldrich, Saint-Louis, CA A5441 1/5000 (WB) FADD Elabscience, Houston, TX E-AB-10318 1/1000 (WB) mouse on mouse kit Vector Lab, Newark, CA BMK2202 Anti-rabbit biotinylated Vector Lab, Newark, CA BA-1000 1/200 (IHC) Histofine kit Microm Microtech, Brignais, France F/414341F Anti-rabbit HRP Cell Signaling, Danvers, MA 7074 1/2000 (WB) Anti-mouse HRP Cell Signaling, Danvers, MA 7076 1/2000 (WB) Figure S1: Schematic representation of experimental models A-B: Generation of Apc∆hep-DLK1/DIO3∆WRE model with AAV8 CRISPR/Cas9 constructs targeting the DLK1-WRE site in Apclox/lox model: tamoxifen-induced Apc deletion was conducted one month after AAV8 injection, which is the time that we have identified as optimal for gene editing2 in pretumoral model (A) and tumoral model (B); C: Generation of β- cateninDExon3 DLK1/DIO3∆WRE model with concomitant injection of AAV8 CRISPR/Cas9 constructs targeting Ctnnb1 and the DLK1-WRE site; D: Kinetics of hepatocyte sorting: GFPpositive hepatocytes were sorted from tumoral Apc∆hep livers in early-steps by flow cytometry (ARIA3, BD).

    Chromatin Immunoprecipitation:

    Article Title: DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis
    Article Snippet: Name Supplier Reference Quantity/Dilution Glutamine synthétase BD Biosciences, Franklin Lakes, NJ 610518 1/400 (IHC) Ki67 Abcam, Cambridge, UK Ab16667 1/300 (IHC) Cleaved Caspase 3 Cell Signaling, Danvers, MA #9661 1/600 (IHC) DLK1 Proteintech, San Diego, CA 10636-1-AP 1/1000 (WB) Cyclin A2 Abcam, Cambridge, UK ab 32386 1/100 (WB) Cyclin B1 Cell Signaling, Danvers, MA 4138 1/200 (WB) FOXM1 Santa Cruz Biotechnology, Dallas, TX sc-376471 X 10ug (CHIP) , 1/100 (IHC) CD45 -PE BD Biosciences, Franklin Lakes, NJ 553081 1/400 (flow cytometry) CD31 – BV605 BioLegend, San Diego, CA 102427 1/300 (flow cytometry) CD11b – BV510 BD Biosciences, Franklin Lakes, NJ 562950 1/400 (flow cytometry) CD11c – PE Cy.7 BD Biosciences, Franklin Lakes, NJ 558079 1/400 (flow cytometry) F4/80 – Percp Cy 5.5 Thermofischer, Waltham, MA 130-118-466 1/300 (flow cytometry) Ly6C – V450 BD Biosciences, Franklin Lakes, NJ 560594 1/200 (flow cytometry) Ly6G – APC Cy.7 BioLegend, San Diego, CA 127624 1/200 (flow cytometry) TCF-4 Millipore, Burlington, MA 05-511 3ug (CHIP) b-catenin BD Biosciences Franklin Lakes, NJ 610154 1/50 (IHC), 10μg (CHIP) HNF-4a Santa-Cruz, Dallas, TX sc-6556x 10μg (CHIP) H3K27ac Active Motif, Carlsbad, CA 39133 10μg (CHIP) H3K4me3 Active Motif, Carlsbad, CA 39159 5 μg (CHIP) H3K4me1 Active Motif, Carlsbad, CA 39297 10μg (CHIP) b-actin Sigma-Aldrich, Saint-Louis, CA A5441 1/5000 (WB) FADD Elabscience, Houston, TX E-AB-10318 1/1000 (WB) mouse on mouse kit Vector Lab, Newark, CA BMK2202 Anti-rabbit biotinylated Vector Lab, Newark, CA BA-1000 1/200 (IHC) Histofine kit Microm Microtech, Brignais, France F/414341F Anti-rabbit HRP Cell Signaling, Danvers, MA 7074 1/2000 (WB) Anti-mouse HRP Cell Signaling, Danvers, MA 7076 1/2000 (WB) 13 Figure S1: Schematic representation of experimental models 14 A-B: Generation of Apc∆hep-DLK1/DIO3∆WRE model with AAV8 CRISPR/Cas9 constructs targeting the DLK1-WRE site in Apclox/lox model: tamoxifen-induced Apc deletion was conducted one month after AAV8 injection, which is the time that we have identified as optimal for gene editing2 in pretumoral model (A) and tumoral model (B); C: Generation of β- cateninDExon3 DLK1/DIO3∆WRE model with concomitant injection of AAV8 CRISPR/Cas9 constructs targeting Ctnnb1 and the DLK1-WRE site; D: Kinetics of hepatocyte sorting: GFP- positive hepatocytes were sorted from tumoral Apc∆hep livers in early-steps by flow cytometry (ARIA3, BD).

    Article Title: DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis
    Article Snippet: Glutamine synthétase BD Biosciences, Franklin Lakes, NJ 610518 1/400 (IHC) Ki67 Abcam, Cambridge, UK Ab16667 1/300 (IHC) Cleaved Caspase 3 Cell Signaling, Danvers, MA #9661 1/600 (IHC) DLK1 Proteintech, San Diego, CA 10636-1-AP 1/1000 (WB) Cyclin A2 Abcam, Cambridge, UK ab 32386 1/100 (WB) Cyclin B1 Cell Signaling, Danvers, MA 4138 1/200 (WB) FOXM1 Santa Cruz Biotechnology, Dallas, TX sc-376471 X 10ug (CHIP) , 1/100 (IHC) CD45 -PE BD Biosciences, Franklin Lakes, NJ 553081 1/400 (flow cytometry) CD31 – BV605 BioLegend, San Diego, CA 102427 1/300 (flow cytometry) CD11b – BV510 BD Biosciences, Franklin Lakes, NJ 562950 1/400 (flow cytometry) CD11c – PE Cy.7 BD Biosciences, Franklin Lakes, NJ 558079 1/400 (flow cytometry) F4/80 – Percp Cy 5.5 Thermofischer, Waltham, MA 130-118-466 1/300 (flow cytometry) Ly6C – V450 BD Biosciences, Franklin Lakes, NJ 560594 1/200 (flow cytometry) Ly6G – APC Cy.7 BioLegend, San Diego, CA 127624 1/200 (flow cytometry) TCF-4 Millipore, Burlington, MA 05-511 3ug (CHIP) b-catenin BD Biosciences Franklin Lakes, NJ 610154 1/50 (IHC), 10μg (CHIP) HNF-4a Santa-Cruz, Dallas, TX sc-6556x 10μg (CHIP) H3K27ac Active Motif, Carlsbad, CA 39133 10μg (CHIP) H3K4me3 Active Motif, Carlsbad, CA 39159 5 μg (CHIP) H3K4me1 Active Motif, Carlsbad, CA 39297 10μg (CHIP) b-actin Sigma-Aldrich, Saint-Louis, CA A5441 1/5000 (WB) FADD Elabscience, Houston, TX E-AB-10318 1/1000 (WB) mouse on mouse kit Vector Lab, Newark, CA BMK2202 Anti-rabbit biotinylated Vector Lab, Newark, CA BA-1000 1/200 (IHC) Histofine kit Microm Microtech, Brignais, France F/414341F Anti-rabbit HRP Cell Signaling, Danvers, MA 7074 1/2000 (WB) Anti-mouse HRP Cell Signaling, Danvers, MA 7076 1/2000 (WB) Figure S1: Schematic representation of experimental models A-B: Generation of Apc∆hep-DLK1/DIO3∆WRE model with AAV8 CRISPR/Cas9 constructs targeting the DLK1-WRE site in Apclox/lox model: tamoxifen-induced Apc deletion was conducted one month after AAV8 injection, which is the time that we have identified as optimal for gene editing2 in pretumoral model (A) and tumoral model (B); C: Generation of β- cateninDExon3 DLK1/DIO3∆WRE model with concomitant injection of AAV8 CRISPR/Cas9 constructs targeting Ctnnb1 and the DLK1-WRE site; D: Kinetics of hepatocyte sorting: GFPpositive hepatocytes were sorted from tumoral Apc∆hep livers in early-steps by flow cytometry (ARIA3, BD).

    Flow Cytometry:

    Article Title: DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis
    Article Snippet: Name Supplier Reference Quantity/Dilution Glutamine synthétase BD Biosciences, Franklin Lakes, NJ 610518 1/400 (IHC) Ki67 Abcam, Cambridge, UK Ab16667 1/300 (IHC) Cleaved Caspase 3 Cell Signaling, Danvers, MA #9661 1/600 (IHC) DLK1 Proteintech, San Diego, CA 10636-1-AP 1/1000 (WB) Cyclin A2 Abcam, Cambridge, UK ab 32386 1/100 (WB) Cyclin B1 Cell Signaling, Danvers, MA 4138 1/200 (WB) FOXM1 Santa Cruz Biotechnology, Dallas, TX sc-376471 X 10ug (CHIP) , 1/100 (IHC) CD45 -PE BD Biosciences, Franklin Lakes, NJ 553081 1/400 (flow cytometry) CD31 – BV605 BioLegend, San Diego, CA 102427 1/300 (flow cytometry) CD11b – BV510 BD Biosciences, Franklin Lakes, NJ 562950 1/400 (flow cytometry) CD11c – PE Cy.7 BD Biosciences, Franklin Lakes, NJ 558079 1/400 (flow cytometry) F4/80 – Percp Cy 5.5 Thermofischer, Waltham, MA 130-118-466 1/300 (flow cytometry) Ly6C – V450 BD Biosciences, Franklin Lakes, NJ 560594 1/200 (flow cytometry) Ly6G – APC Cy.7 BioLegend, San Diego, CA 127624 1/200 (flow cytometry) TCF-4 Millipore, Burlington, MA 05-511 3ug (CHIP) b-catenin BD Biosciences Franklin Lakes, NJ 610154 1/50 (IHC), 10μg (CHIP) HNF-4a Santa-Cruz, Dallas, TX sc-6556x 10μg (CHIP) H3K27ac Active Motif, Carlsbad, CA 39133 10μg (CHIP) H3K4me3 Active Motif, Carlsbad, CA 39159 5 μg (CHIP) H3K4me1 Active Motif, Carlsbad, CA 39297 10μg (CHIP) b-actin Sigma-Aldrich, Saint-Louis, CA A5441 1/5000 (WB) FADD Elabscience, Houston, TX E-AB-10318 1/1000 (WB) mouse on mouse kit Vector Lab, Newark, CA BMK2202 Anti-rabbit biotinylated Vector Lab, Newark, CA BA-1000 1/200 (IHC) Histofine kit Microm Microtech, Brignais, France F/414341F Anti-rabbit HRP Cell Signaling, Danvers, MA 7074 1/2000 (WB) Anti-mouse HRP Cell Signaling, Danvers, MA 7076 1/2000 (WB) 13 Figure S1: Schematic representation of experimental models 14 A-B: Generation of Apc∆hep-DLK1/DIO3∆WRE model with AAV8 CRISPR/Cas9 constructs targeting the DLK1-WRE site in Apclox/lox model: tamoxifen-induced Apc deletion was conducted one month after AAV8 injection, which is the time that we have identified as optimal for gene editing2 in pretumoral model (A) and tumoral model (B); C: Generation of β- cateninDExon3 DLK1/DIO3∆WRE model with concomitant injection of AAV8 CRISPR/Cas9 constructs targeting Ctnnb1 and the DLK1-WRE site; D: Kinetics of hepatocyte sorting: GFP- positive hepatocytes were sorted from tumoral Apc∆hep livers in early-steps by flow cytometry (ARIA3, BD).

    Article Title: DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis
    Article Snippet: Glutamine synthétase BD Biosciences, Franklin Lakes, NJ 610518 1/400 (IHC) Ki67 Abcam, Cambridge, UK Ab16667 1/300 (IHC) Cleaved Caspase 3 Cell Signaling, Danvers, MA #9661 1/600 (IHC) DLK1 Proteintech, San Diego, CA 10636-1-AP 1/1000 (WB) Cyclin A2 Abcam, Cambridge, UK ab 32386 1/100 (WB) Cyclin B1 Cell Signaling, Danvers, MA 4138 1/200 (WB) FOXM1 Santa Cruz Biotechnology, Dallas, TX sc-376471 X 10ug (CHIP) , 1/100 (IHC) CD45 -PE BD Biosciences, Franklin Lakes, NJ 553081 1/400 (flow cytometry) CD31 – BV605 BioLegend, San Diego, CA 102427 1/300 (flow cytometry) CD11b – BV510 BD Biosciences, Franklin Lakes, NJ 562950 1/400 (flow cytometry) CD11c – PE Cy.7 BD Biosciences, Franklin Lakes, NJ 558079 1/400 (flow cytometry) F4/80 – Percp Cy 5.5 Thermofischer, Waltham, MA 130-118-466 1/300 (flow cytometry) Ly6C – V450 BD Biosciences, Franklin Lakes, NJ 560594 1/200 (flow cytometry) Ly6G – APC Cy.7 BioLegend, San Diego, CA 127624 1/200 (flow cytometry) TCF-4 Millipore, Burlington, MA 05-511 3ug (CHIP) b-catenin BD Biosciences Franklin Lakes, NJ 610154 1/50 (IHC), 10μg (CHIP) HNF-4a Santa-Cruz, Dallas, TX sc-6556x 10μg (CHIP) H3K27ac Active Motif, Carlsbad, CA 39133 10μg (CHIP) H3K4me3 Active Motif, Carlsbad, CA 39159 5 μg (CHIP) H3K4me1 Active Motif, Carlsbad, CA 39297 10μg (CHIP) b-actin Sigma-Aldrich, Saint-Louis, CA A5441 1/5000 (WB) FADD Elabscience, Houston, TX E-AB-10318 1/1000 (WB) mouse on mouse kit Vector Lab, Newark, CA BMK2202 Anti-rabbit biotinylated Vector Lab, Newark, CA BA-1000 1/200 (IHC) Histofine kit Microm Microtech, Brignais, France F/414341F Anti-rabbit HRP Cell Signaling, Danvers, MA 7074 1/2000 (WB) Anti-mouse HRP Cell Signaling, Danvers, MA 7076 1/2000 (WB) Figure S1: Schematic representation of experimental models A-B: Generation of Apc∆hep-DLK1/DIO3∆WRE model with AAV8 CRISPR/Cas9 constructs targeting the DLK1-WRE site in Apclox/lox model: tamoxifen-induced Apc deletion was conducted one month after AAV8 injection, which is the time that we have identified as optimal for gene editing2 in pretumoral model (A) and tumoral model (B); C: Generation of β- cateninDExon3 DLK1/DIO3∆WRE model with concomitant injection of AAV8 CRISPR/Cas9 constructs targeting Ctnnb1 and the DLK1-WRE site; D: Kinetics of hepatocyte sorting: GFPpositive hepatocytes were sorted from tumoral Apc∆hep livers in early-steps by flow cytometry (ARIA3, BD).

    CRISPR:

    Article Title: DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis
    Article Snippet: Name Supplier Reference Quantity/Dilution Glutamine synthétase BD Biosciences, Franklin Lakes, NJ 610518 1/400 (IHC) Ki67 Abcam, Cambridge, UK Ab16667 1/300 (IHC) Cleaved Caspase 3 Cell Signaling, Danvers, MA #9661 1/600 (IHC) DLK1 Proteintech, San Diego, CA 10636-1-AP 1/1000 (WB) Cyclin A2 Abcam, Cambridge, UK ab 32386 1/100 (WB) Cyclin B1 Cell Signaling, Danvers, MA 4138 1/200 (WB) FOXM1 Santa Cruz Biotechnology, Dallas, TX sc-376471 X 10ug (CHIP) , 1/100 (IHC) CD45 -PE BD Biosciences, Franklin Lakes, NJ 553081 1/400 (flow cytometry) CD31 – BV605 BioLegend, San Diego, CA 102427 1/300 (flow cytometry) CD11b – BV510 BD Biosciences, Franklin Lakes, NJ 562950 1/400 (flow cytometry) CD11c – PE Cy.7 BD Biosciences, Franklin Lakes, NJ 558079 1/400 (flow cytometry) F4/80 – Percp Cy 5.5 Thermofischer, Waltham, MA 130-118-466 1/300 (flow cytometry) Ly6C – V450 BD Biosciences, Franklin Lakes, NJ 560594 1/200 (flow cytometry) Ly6G – APC Cy.7 BioLegend, San Diego, CA 127624 1/200 (flow cytometry) TCF-4 Millipore, Burlington, MA 05-511 3ug (CHIP) b-catenin BD Biosciences Franklin Lakes, NJ 610154 1/50 (IHC), 10μg (CHIP) HNF-4a Santa-Cruz, Dallas, TX sc-6556x 10μg (CHIP) H3K27ac Active Motif, Carlsbad, CA 39133 10μg (CHIP) H3K4me3 Active Motif, Carlsbad, CA 39159 5 μg (CHIP) H3K4me1 Active Motif, Carlsbad, CA 39297 10μg (CHIP) b-actin Sigma-Aldrich, Saint-Louis, CA A5441 1/5000 (WB) FADD Elabscience, Houston, TX E-AB-10318 1/1000 (WB) mouse on mouse kit Vector Lab, Newark, CA BMK2202 Anti-rabbit biotinylated Vector Lab, Newark, CA BA-1000 1/200 (IHC) Histofine kit Microm Microtech, Brignais, France F/414341F Anti-rabbit HRP Cell Signaling, Danvers, MA 7074 1/2000 (WB) Anti-mouse HRP Cell Signaling, Danvers, MA 7076 1/2000 (WB) 13 Figure S1: Schematic representation of experimental models 14 A-B: Generation of Apc∆hep-DLK1/DIO3∆WRE model with AAV8 CRISPR/Cas9 constructs targeting the DLK1-WRE site in Apclox/lox model: tamoxifen-induced Apc deletion was conducted one month after AAV8 injection, which is the time that we have identified as optimal for gene editing2 in pretumoral model (A) and tumoral model (B); C: Generation of β- cateninDExon3 DLK1/DIO3∆WRE model with concomitant injection of AAV8 CRISPR/Cas9 constructs targeting Ctnnb1 and the DLK1-WRE site; D: Kinetics of hepatocyte sorting: GFP- positive hepatocytes were sorted from tumoral Apc∆hep livers in early-steps by flow cytometry (ARIA3, BD).

    Article Title: DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis
    Article Snippet: Glutamine synthétase BD Biosciences, Franklin Lakes, NJ 610518 1/400 (IHC) Ki67 Abcam, Cambridge, UK Ab16667 1/300 (IHC) Cleaved Caspase 3 Cell Signaling, Danvers, MA #9661 1/600 (IHC) DLK1 Proteintech, San Diego, CA 10636-1-AP 1/1000 (WB) Cyclin A2 Abcam, Cambridge, UK ab 32386 1/100 (WB) Cyclin B1 Cell Signaling, Danvers, MA 4138 1/200 (WB) FOXM1 Santa Cruz Biotechnology, Dallas, TX sc-376471 X 10ug (CHIP) , 1/100 (IHC) CD45 -PE BD Biosciences, Franklin Lakes, NJ 553081 1/400 (flow cytometry) CD31 – BV605 BioLegend, San Diego, CA 102427 1/300 (flow cytometry) CD11b – BV510 BD Biosciences, Franklin Lakes, NJ 562950 1/400 (flow cytometry) CD11c – PE Cy.7 BD Biosciences, Franklin Lakes, NJ 558079 1/400 (flow cytometry) F4/80 – Percp Cy 5.5 Thermofischer, Waltham, MA 130-118-466 1/300 (flow cytometry) Ly6C – V450 BD Biosciences, Franklin Lakes, NJ 560594 1/200 (flow cytometry) Ly6G – APC Cy.7 BioLegend, San Diego, CA 127624 1/200 (flow cytometry) TCF-4 Millipore, Burlington, MA 05-511 3ug (CHIP) b-catenin BD Biosciences Franklin Lakes, NJ 610154 1/50 (IHC), 10μg (CHIP) HNF-4a Santa-Cruz, Dallas, TX sc-6556x 10μg (CHIP) H3K27ac Active Motif, Carlsbad, CA 39133 10μg (CHIP) H3K4me3 Active Motif, Carlsbad, CA 39159 5 μg (CHIP) H3K4me1 Active Motif, Carlsbad, CA 39297 10μg (CHIP) b-actin Sigma-Aldrich, Saint-Louis, CA A5441 1/5000 (WB) FADD Elabscience, Houston, TX E-AB-10318 1/1000 (WB) mouse on mouse kit Vector Lab, Newark, CA BMK2202 Anti-rabbit biotinylated Vector Lab, Newark, CA BA-1000 1/200 (IHC) Histofine kit Microm Microtech, Brignais, France F/414341F Anti-rabbit HRP Cell Signaling, Danvers, MA 7074 1/2000 (WB) Anti-mouse HRP Cell Signaling, Danvers, MA 7076 1/2000 (WB) Figure S1: Schematic representation of experimental models A-B: Generation of Apc∆hep-DLK1/DIO3∆WRE model with AAV8 CRISPR/Cas9 constructs targeting the DLK1-WRE site in Apclox/lox model: tamoxifen-induced Apc deletion was conducted one month after AAV8 injection, which is the time that we have identified as optimal for gene editing2 in pretumoral model (A) and tumoral model (B); C: Generation of β- cateninDExon3 DLK1/DIO3∆WRE model with concomitant injection of AAV8 CRISPR/Cas9 constructs targeting Ctnnb1 and the DLK1-WRE site; D: Kinetics of hepatocyte sorting: GFPpositive hepatocytes were sorted from tumoral Apc∆hep livers in early-steps by flow cytometry (ARIA3, BD).

    Construct:

    Article Title: DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis
    Article Snippet: Name Supplier Reference Quantity/Dilution Glutamine synthétase BD Biosciences, Franklin Lakes, NJ 610518 1/400 (IHC) Ki67 Abcam, Cambridge, UK Ab16667 1/300 (IHC) Cleaved Caspase 3 Cell Signaling, Danvers, MA #9661 1/600 (IHC) DLK1 Proteintech, San Diego, CA 10636-1-AP 1/1000 (WB) Cyclin A2 Abcam, Cambridge, UK ab 32386 1/100 (WB) Cyclin B1 Cell Signaling, Danvers, MA 4138 1/200 (WB) FOXM1 Santa Cruz Biotechnology, Dallas, TX sc-376471 X 10ug (CHIP) , 1/100 (IHC) CD45 -PE BD Biosciences, Franklin Lakes, NJ 553081 1/400 (flow cytometry) CD31 – BV605 BioLegend, San Diego, CA 102427 1/300 (flow cytometry) CD11b – BV510 BD Biosciences, Franklin Lakes, NJ 562950 1/400 (flow cytometry) CD11c – PE Cy.7 BD Biosciences, Franklin Lakes, NJ 558079 1/400 (flow cytometry) F4/80 – Percp Cy 5.5 Thermofischer, Waltham, MA 130-118-466 1/300 (flow cytometry) Ly6C – V450 BD Biosciences, Franklin Lakes, NJ 560594 1/200 (flow cytometry) Ly6G – APC Cy.7 BioLegend, San Diego, CA 127624 1/200 (flow cytometry) TCF-4 Millipore, Burlington, MA 05-511 3ug (CHIP) b-catenin BD Biosciences Franklin Lakes, NJ 610154 1/50 (IHC), 10μg (CHIP) HNF-4a Santa-Cruz, Dallas, TX sc-6556x 10μg (CHIP) H3K27ac Active Motif, Carlsbad, CA 39133 10μg (CHIP) H3K4me3 Active Motif, Carlsbad, CA 39159 5 μg (CHIP) H3K4me1 Active Motif, Carlsbad, CA 39297 10μg (CHIP) b-actin Sigma-Aldrich, Saint-Louis, CA A5441 1/5000 (WB) FADD Elabscience, Houston, TX E-AB-10318 1/1000 (WB) mouse on mouse kit Vector Lab, Newark, CA BMK2202 Anti-rabbit biotinylated Vector Lab, Newark, CA BA-1000 1/200 (IHC) Histofine kit Microm Microtech, Brignais, France F/414341F Anti-rabbit HRP Cell Signaling, Danvers, MA 7074 1/2000 (WB) Anti-mouse HRP Cell Signaling, Danvers, MA 7076 1/2000 (WB) 13 Figure S1: Schematic representation of experimental models 14 A-B: Generation of Apc∆hep-DLK1/DIO3∆WRE model with AAV8 CRISPR/Cas9 constructs targeting the DLK1-WRE site in Apclox/lox model: tamoxifen-induced Apc deletion was conducted one month after AAV8 injection, which is the time that we have identified as optimal for gene editing2 in pretumoral model (A) and tumoral model (B); C: Generation of β- cateninDExon3 DLK1/DIO3∆WRE model with concomitant injection of AAV8 CRISPR/Cas9 constructs targeting Ctnnb1 and the DLK1-WRE site; D: Kinetics of hepatocyte sorting: GFP- positive hepatocytes were sorted from tumoral Apc∆hep livers in early-steps by flow cytometry (ARIA3, BD).

    Article Title: DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis
    Article Snippet: Glutamine synthétase BD Biosciences, Franklin Lakes, NJ 610518 1/400 (IHC) Ki67 Abcam, Cambridge, UK Ab16667 1/300 (IHC) Cleaved Caspase 3 Cell Signaling, Danvers, MA #9661 1/600 (IHC) DLK1 Proteintech, San Diego, CA 10636-1-AP 1/1000 (WB) Cyclin A2 Abcam, Cambridge, UK ab 32386 1/100 (WB) Cyclin B1 Cell Signaling, Danvers, MA 4138 1/200 (WB) FOXM1 Santa Cruz Biotechnology, Dallas, TX sc-376471 X 10ug (CHIP) , 1/100 (IHC) CD45 -PE BD Biosciences, Franklin Lakes, NJ 553081 1/400 (flow cytometry) CD31 – BV605 BioLegend, San Diego, CA 102427 1/300 (flow cytometry) CD11b – BV510 BD Biosciences, Franklin Lakes, NJ 562950 1/400 (flow cytometry) CD11c – PE Cy.7 BD Biosciences, Franklin Lakes, NJ 558079 1/400 (flow cytometry) F4/80 – Percp Cy 5.5 Thermofischer, Waltham, MA 130-118-466 1/300 (flow cytometry) Ly6C – V450 BD Biosciences, Franklin Lakes, NJ 560594 1/200 (flow cytometry) Ly6G – APC Cy.7 BioLegend, San Diego, CA 127624 1/200 (flow cytometry) TCF-4 Millipore, Burlington, MA 05-511 3ug (CHIP) b-catenin BD Biosciences Franklin Lakes, NJ 610154 1/50 (IHC), 10μg (CHIP) HNF-4a Santa-Cruz, Dallas, TX sc-6556x 10μg (CHIP) H3K27ac Active Motif, Carlsbad, CA 39133 10μg (CHIP) H3K4me3 Active Motif, Carlsbad, CA 39159 5 μg (CHIP) H3K4me1 Active Motif, Carlsbad, CA 39297 10μg (CHIP) b-actin Sigma-Aldrich, Saint-Louis, CA A5441 1/5000 (WB) FADD Elabscience, Houston, TX E-AB-10318 1/1000 (WB) mouse on mouse kit Vector Lab, Newark, CA BMK2202 Anti-rabbit biotinylated Vector Lab, Newark, CA BA-1000 1/200 (IHC) Histofine kit Microm Microtech, Brignais, France F/414341F Anti-rabbit HRP Cell Signaling, Danvers, MA 7074 1/2000 (WB) Anti-mouse HRP Cell Signaling, Danvers, MA 7076 1/2000 (WB) Figure S1: Schematic representation of experimental models A-B: Generation of Apc∆hep-DLK1/DIO3∆WRE model with AAV8 CRISPR/Cas9 constructs targeting the DLK1-WRE site in Apclox/lox model: tamoxifen-induced Apc deletion was conducted one month after AAV8 injection, which is the time that we have identified as optimal for gene editing2 in pretumoral model (A) and tumoral model (B); C: Generation of β- cateninDExon3 DLK1/DIO3∆WRE model with concomitant injection of AAV8 CRISPR/Cas9 constructs targeting Ctnnb1 and the DLK1-WRE site; D: Kinetics of hepatocyte sorting: GFPpositive hepatocytes were sorted from tumoral Apc∆hep livers in early-steps by flow cytometry (ARIA3, BD).

    Injection:

    Article Title: DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis
    Article Snippet: Name Supplier Reference Quantity/Dilution Glutamine synthétase BD Biosciences, Franklin Lakes, NJ 610518 1/400 (IHC) Ki67 Abcam, Cambridge, UK Ab16667 1/300 (IHC) Cleaved Caspase 3 Cell Signaling, Danvers, MA #9661 1/600 (IHC) DLK1 Proteintech, San Diego, CA 10636-1-AP 1/1000 (WB) Cyclin A2 Abcam, Cambridge, UK ab 32386 1/100 (WB) Cyclin B1 Cell Signaling, Danvers, MA 4138 1/200 (WB) FOXM1 Santa Cruz Biotechnology, Dallas, TX sc-376471 X 10ug (CHIP) , 1/100 (IHC) CD45 -PE BD Biosciences, Franklin Lakes, NJ 553081 1/400 (flow cytometry) CD31 – BV605 BioLegend, San Diego, CA 102427 1/300 (flow cytometry) CD11b – BV510 BD Biosciences, Franklin Lakes, NJ 562950 1/400 (flow cytometry) CD11c – PE Cy.7 BD Biosciences, Franklin Lakes, NJ 558079 1/400 (flow cytometry) F4/80 – Percp Cy 5.5 Thermofischer, Waltham, MA 130-118-466 1/300 (flow cytometry) Ly6C – V450 BD Biosciences, Franklin Lakes, NJ 560594 1/200 (flow cytometry) Ly6G – APC Cy.7 BioLegend, San Diego, CA 127624 1/200 (flow cytometry) TCF-4 Millipore, Burlington, MA 05-511 3ug (CHIP) b-catenin BD Biosciences Franklin Lakes, NJ 610154 1/50 (IHC), 10μg (CHIP) HNF-4a Santa-Cruz, Dallas, TX sc-6556x 10μg (CHIP) H3K27ac Active Motif, Carlsbad, CA 39133 10μg (CHIP) H3K4me3 Active Motif, Carlsbad, CA 39159 5 μg (CHIP) H3K4me1 Active Motif, Carlsbad, CA 39297 10μg (CHIP) b-actin Sigma-Aldrich, Saint-Louis, CA A5441 1/5000 (WB) FADD Elabscience, Houston, TX E-AB-10318 1/1000 (WB) mouse on mouse kit Vector Lab, Newark, CA BMK2202 Anti-rabbit biotinylated Vector Lab, Newark, CA BA-1000 1/200 (IHC) Histofine kit Microm Microtech, Brignais, France F/414341F Anti-rabbit HRP Cell Signaling, Danvers, MA 7074 1/2000 (WB) Anti-mouse HRP Cell Signaling, Danvers, MA 7076 1/2000 (WB) 13 Figure S1: Schematic representation of experimental models 14 A-B: Generation of Apc∆hep-DLK1/DIO3∆WRE model with AAV8 CRISPR/Cas9 constructs targeting the DLK1-WRE site in Apclox/lox model: tamoxifen-induced Apc deletion was conducted one month after AAV8 injection, which is the time that we have identified as optimal for gene editing2 in pretumoral model (A) and tumoral model (B); C: Generation of β- cateninDExon3 DLK1/DIO3∆WRE model with concomitant injection of AAV8 CRISPR/Cas9 constructs targeting Ctnnb1 and the DLK1-WRE site; D: Kinetics of hepatocyte sorting: GFP- positive hepatocytes were sorted from tumoral Apc∆hep livers in early-steps by flow cytometry (ARIA3, BD).

    Article Title: DLK1/DIO3 locus upregulation by a β-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis
    Article Snippet: Glutamine synthétase BD Biosciences, Franklin Lakes, NJ 610518 1/400 (IHC) Ki67 Abcam, Cambridge, UK Ab16667 1/300 (IHC) Cleaved Caspase 3 Cell Signaling, Danvers, MA #9661 1/600 (IHC) DLK1 Proteintech, San Diego, CA 10636-1-AP 1/1000 (WB) Cyclin A2 Abcam, Cambridge, UK ab 32386 1/100 (WB) Cyclin B1 Cell Signaling, Danvers, MA 4138 1/200 (WB) FOXM1 Santa Cruz Biotechnology, Dallas, TX sc-376471 X 10ug (CHIP) , 1/100 (IHC) CD45 -PE BD Biosciences, Franklin Lakes, NJ 553081 1/400 (flow cytometry) CD31 – BV605 BioLegend, San Diego, CA 102427 1/300 (flow cytometry) CD11b – BV510 BD Biosciences, Franklin Lakes, NJ 562950 1/400 (flow cytometry) CD11c – PE Cy.7 BD Biosciences, Franklin Lakes, NJ 558079 1/400 (flow cytometry) F4/80 – Percp Cy 5.5 Thermofischer, Waltham, MA 130-118-466 1/300 (flow cytometry) Ly6C – V450 BD Biosciences, Franklin Lakes, NJ 560594 1/200 (flow cytometry) Ly6G – APC Cy.7 BioLegend, San Diego, CA 127624 1/200 (flow cytometry) TCF-4 Millipore, Burlington, MA 05-511 3ug (CHIP) b-catenin BD Biosciences Franklin Lakes, NJ 610154 1/50 (IHC), 10μg (CHIP) HNF-4a Santa-Cruz, Dallas, TX sc-6556x 10μg (CHIP) H3K27ac Active Motif, Carlsbad, CA 39133 10μg (CHIP) H3K4me3 Active Motif, Carlsbad, CA 39159 5 μg (CHIP) H3K4me1 Active Motif, Carlsbad, CA 39297 10μg (CHIP) b-actin Sigma-Aldrich, Saint-Louis, CA A5441 1/5000 (WB) FADD Elabscience, Houston, TX E-AB-10318 1/1000 (WB) mouse on mouse kit Vector Lab, Newark, CA BMK2202 Anti-rabbit biotinylated Vector Lab, Newark, CA BA-1000 1/200 (IHC) Histofine kit Microm Microtech, Brignais, France F/414341F Anti-rabbit HRP Cell Signaling, Danvers, MA 7074 1/2000 (WB) Anti-mouse HRP Cell Signaling, Danvers, MA 7076 1/2000 (WB) Figure S1: Schematic representation of experimental models A-B: Generation of Apc∆hep-DLK1/DIO3∆WRE model with AAV8 CRISPR/Cas9 constructs targeting the DLK1-WRE site in Apclox/lox model: tamoxifen-induced Apc deletion was conducted one month after AAV8 injection, which is the time that we have identified as optimal for gene editing2 in pretumoral model (A) and tumoral model (B); C: Generation of β- cateninDExon3 DLK1/DIO3∆WRE model with concomitant injection of AAV8 CRISPR/Cas9 constructs targeting Ctnnb1 and the DLK1-WRE site; D: Kinetics of hepatocyte sorting: GFPpositive hepatocytes were sorted from tumoral Apc∆hep livers in early-steps by flow cytometry (ARIA3, BD).



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